Paxillin (PXN) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 1:500-1:2000
Reactivity	Human, Mouse, Rat
Modifications	Phospho-specific
Host	Rabbit
Clonality	Polyclonal
Immunogen	The immunogen for anti-Phospho-Paxillin(Ser178) Antibody: A synthesized peptide derived from human Paxillin around the phosphorylation site of Sersine 178
Formulation	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20?. Stable for 12 months from date of receipt
Concentration	lot specific
Purification	Immunogen affinity purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	64 kDa
Gene Name	paxillin
Database Link	NP_002850 Entrez Gene 19303 MouseEntrez Gene 360820 RatEntrez Gene 5829 Human UniProt ID P49023
Background	PXN is a multi-domain cytoskeletal protein that localizes primarily to focal adhesion sites to the extracellular matrix. Phosphorylated by focal adhesion kinase (FAK) and is a component of integrin signaling. Its phosphorylation provides docking sites for recruitment of signaling molecules to focal adhesions. The SH2 domain of Crk binds to tyrosine phosphorylated paxillin. Three alternatively-spliced isoforms have been described.
Synonyms	FLJ16691
Note	Phospho-Paxillin(Ser178) Antibody detects endogenous levels of Paxillin only when phosphorylated at Sersine 178
Reference Data
Protein Families	Druggable Genome, Stem cell - Pluripotency
Protein Pathways	Chemokine signaling pathway, Focal adhesion, Leukocyte transendothelial migration, Regulation of actin cytoskeleton, VEGF signaling pathway

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