LRAT Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 1:500-1:2000
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	The immunogen for anti-LRAT Antibody: A synthesized peptide derived from human LRAT
Formulation	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20?. Stable for 12 months from date of receipt
Concentration	lot specific
Purification	Immunogen affinity purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	27 kDa
Gene Name	lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase)
Database Link	NP_004735 Entrez Gene 64047 RatEntrez Gene 79235 MouseEntrez Gene 9227 Human UniProt ID O95237
Background	LRAT Transfers the acyl group from the sn-1 position of phosphatidylcholine to all-trans retinol, producing all-trans retinyl esters. Retinyl esters are storage forms of vitamin A. LRAT plays a critical role in vision. It provides the all-trans retinyl ester substrates for the isomerohydrolase which processes the esters into 11-cis-retinol in the retinal pigment epithelium; due to a membrane-associated alcohol dehydrogenase, 11 cis-retinol is oxidized and converted into 11-cis-retinaldehyde which is the chromophore for rhodopsin and the cone photopigments. Belongs to the H-rev107 family. LRAT activity is up-regulated by dietary vitamin A.
Synonyms	LCA14
Note	LRAT Antibody detects endogenous levels of LRAT
Reference Data
Protein Families	Druggable Genome, Transmembrane
Protein Pathways	Retinol metabolism

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