MBD1 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, WB
Recommend Dilution	ChIP (1.5 µg); ELISA (1:1,000); Western blotting (1:500)
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	The immunogen for anti-MBD1 antibody: human MBD1 (Methyl-CpG-binding domain protein 1), using a KLH-conjugated synthetic peptide containing a sequence from the N-terminal part of the protein.
Concentration	lot specific
Purification	Affinity purified polyclonal antibody in PBS containing 0.05% azide and 0.05% ProClin 300.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	methyl-CpG binding domain protein 1
Database Link	NP_056669 Entrez Gene 4152 Human UniProt ID Q9UIS9
Background	MBD1 (UniProt/Swiss-Prot entry Q9UIS9) is a transcriptional repressor that specifically binds to methylated CpG dinucleotides in promoter sequences. MBD1 acts by recruiting a variety of histone deacetylases (HDAC's) and chromatin remodelling factors. MBD1-dependent transcriptional repression is mediated by ATF7IP through the recruitment of factors such as the histone methyltransferase SETDB1. MBD1 probably forms a complex with SETDB1 and ATF7IP which couples DNA methylation to H3K9 trimethylation and represses transcription.
Synonyms	CXXC3; PCM1; RFT
Reference Data
Protein Families	Druggable Genome, Transcription Factors

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