H4-16 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	Dot, ELISA
Recommend Dilution	ChIP (2-5ug/IP); ELISA (1:500); Dot Blotting (1:10.000
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	The immunogen for anti-H4 pan antibody: histone H4 using a KLH-conjugated synthetic peptide containing an unmodified sequence from the central part of the protein.
Concentration	lot specific
Purification	Affinity purified polyclonal antibody in PBS containing 0.05% azide and 0.05% ProClin 300.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	histone cluster 4, H4
Database Link	NP_778224 Entrez Gene 121504 Human UniProt ID P62805
Background	Histones are the main constituents of the protein part of chromosomes of eukaryotic cells. They are rich in the amino acids arginine and lysine and have been greatly conserved during evolution. Histones pack the DNA into tight masses of chromatin. Two core histones of each class H2A, H2B, H3 and H4 assemble and are wrapped by 146 base pairs of DNA to form one octameric nucleosome. Histones play a central role in the regulation of transcription, DNA repair, DNA replication and chromosomal stability. These different functions are established via a complex set of post-translational modifications which either directly or indirectly alter chromatin structure and DNA accessibility to facilitate transcriptional activation or repression or other nuclear processes.
Synonyms	H4; p
Reference Data
Protein Pathways	Systemic lupus erythematosus

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