H3FA (HIST1H3A) Mouse Monoclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	ChIP (1-2 µg per IP); Western blotting (1:1,000)
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	The immunogen for anti-H3 pan antibody: histone H3, using a KLH-conjugated synthetic peptide containing an unmodified sequence from the C-terminus of the protein.
Concentration	lot specific
Purification	Protein A purified monoclonal antibody in PBS containing 0.05% azide.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	histone cluster 1, H3a
Database Link	NP_003520 Entrez Gene 8350 Human UniProt ID P68431
Background	Histones are the main constituents of the protein part of chromosomes of eukaryotic cells. They are rich in the amino acids arginine and lysine and have been greatly conserved during evolution. Histones pack the DNA into tight masses of chromatin. Two core histones of each class H2A, H2B, H3 and H4 assemble and are wrapped by 146 base pairs of DNA to form one octameric nucleosome. Histones play a central role in the regulation of transcription, DNA repair, DNA replication and chromosomal stability. These different functions are established via a complex set of post-translational modifications which either directly or indirectly alter chromatin structure and DNA accessibility to facilitate transcriptional activation or repression or other nuclear processes.
Synonyms	A; H3; H3FA
Reference Data
Protein Pathways	Systemic lupus erythematosus

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