HP1 alpha (CBX5) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, WB
Recommend Dilution	Western blotting (1:1,000); IF: (1:500)
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	The immunogen for anti-HP1. antibody: human HP1. (Heterochromatin protein 1 homolog alpha), using the full length recombinant GST tagged protein.
Concentration	lot specific
Purification	Protein G purified polyclonal antibody in PBS containing 0.05% azide and 0.05% ProClin 300.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	chromobox 5
Database Link	NP_036249 Entrez Gene 23468 Human UniProt ID P45973
Background	HP1 alpha (UniProt/Swiss-Prot entry P45973) is a component of heterochromatin. It recognizes and binds to histone H3 tails methylated at 'Lys-9', leading to epigenetic repression of transcription. HP1 alpha may also interact with lamin B receptor (LBR), thereby contributing to the association of the heterochromatin with the inner nuclear membrane. Further, HP1 alpha is involved in the formation of a functional kinetochore through interaction with MIS12 complex proteins.
Synonyms	HEL25; HP1; HP1A
Reference Data

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