Ku80 (XRCC5) Mouse Monoclonal Antibody [Clone ID: 8H1-C3-G10]

Specifications

Product Data
Clone Name	8H1-C3-G10
Applications	IF, IP, WB
Recommend Dilution	WB: 1:1000, IF: 1:400, IP: 1:100
Reactivity	Human, Monkey
Host	Mouse
Clonality	Monoclonal
Immunogen	The immunogen for XRCC5 antibody: purified recombinant human Ku80 protein fragments expressed in E.coli
Formulation	Purified mouse monoclonal antibody in PBS(pH 7.4) containing with 0.02% sodium azide and 50% glycerol.
Purification	Affinity purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	86 kDa
Gene Name	X-ray repair complementing defective repair in Chinese hamster cells 5
Database Link	NP_066964 Entrez Gene 574279 MonkeyEntrez Gene 7520 Human UniProt ID P13010
Background	The protein encoded by this gene is the 80-kilodalton subunit of the Ku heterodimer protein which is also known as ATP-dependant DNA helicase II or DNA repair protein XRCC5. Ku is the DNA-binding component of the DNA-dependent protein kinase, and it functions together with the DNA ligase IV-XRCC4 complex in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. This gene functionally complements Chinese hamster xrs-6, a mutant defective in DNA double-strand break repair and in ability to undergo V(D)J recombination. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. (provided by RefSeq, Jul 2008).
Synonyms	KARP-1; KARP1; KU80; Ku86; KUB2; NFIV
Reference Data
Protein Families	Druggable Genome, Stem cell - Pluripotency
Protein Pathways	Non-homologous end-joining

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