TBL1 (TBL1X) Mouse Monoclonal Antibody [Clone ID: 4H2-D5-E9]

Specifications

Product Data
Clone Name	4H2-D5-E9
Applications	IF, WB
Recommend Dilution	WB: 1:1000, IF: 1:100
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	The immunogen for TBL1X antibody: purified recombinant human TBL1 protein fragments expressed in E.coli.
Formulation	Purified mouse monoclonal antibody in PBS(pH 7.4) containing with 0.02% sodium azide and 50% glycerol.
Purification	Affinity purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	58 kDa
Gene Name	transducin (beta)-like 1X-linked
Database Link	NP_005638 Entrez Gene 6907 Human UniProt ID O60907
Background	The protein encoded by this gene has sequence similarity with members of the WD40 repeat-containing protein family. The WD40 group is a large family of proteins, which appear to have a regulatory function. It is believed that the WD40 repeats mediate protein-protein interactions and members of the family are involved in signal transduction, RNA processing, gene regulation, vesicular trafficking, cytoskeletal assembly and may play a role in the control of cytotypic differentiation. This encoded protein is found as a subunit in corepressor SMRT (silencing mediator for retinoid and thyroid receptors) complex along with histone deacetylase 3 protein. This gene is located adjacent to the ocular albinism gene and it is thought to be involved in the pathogenesis of the ocular albinism with late-onset sensorineural deafness phenotype. Four transcript variants encoding two different isoforms have been found for this gene. This gene is highly similar to the Y chromosome TBL1Y gene. [provided by RefSeq, Nov 2008]
Synonyms	EBI; SMAP55; TBL1
Reference Data
Protein Families	Transcription Factors
Protein Pathways	Wnt signaling pathway

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