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PDHA1 Mouse Monoclonal Antibody [Clone ID: 3H2-F8-B5]
CAT＃: TA347015S
Mouse Monoclonal pyruvate dehydrogenase (lipoamide) alpha 1 Antibody
Size: 100 ul
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CNY 800.00
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Specifications
| Product Data | |
| Clone Name | 3H2-F8-B5 |
| Applications | IF, WB |
| Recommend Dilution | WB: 1:1000, IF: 1:100 |
| Reactivity | Human, Mouse |
| Host | Mouse |
| Clonality | Monoclonal |
| Immunogen | The immunogen for PDHA1 antibody: purified recombinant human Pyruvate Dehydrogenase protein fragments expressed in E.coli. |
| Formulation | Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.02% sodium azide, 50%,glycerol |
| Purification | Affinity purified |
| Conjugation | Unconjugated |
| Storage Condition | Store at -20°C as received. |
| Predicted Protein Size | 43 kDa |
| Gene Name | pyruvate dehydrogenase (lipoamide) alpha 1 |
| Database Link | |
| Background | The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle. The PDH complex is composed of multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). The E1 enzyme is a heterotetramer of two alpha and two beta subunits. This gene encodes the E1 alpha 1 subunit containing the E1 active site, and plays a key role in the function of the PDH complex. Mutations in this gene are associated with pyruvate dehydrogenase E1-alpha deficiency and X-linked Leigh syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
| Synonyms | PDHA; PDHAD; PDHCE1A; PHE1A |
| Reference Data | |
| Protein Families | Druggable Genome |
| Protein Pathways | Butanoate metabolism, Citrate cycle (TCA cycle), Glycolysis / Gluconeogenesis, Metabolic pathways, Pyruvate metabolism, Valine, leucine and isoleucine biosynthesis |
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