Noggin (NOG) Mouse Monoclonal Antibody [Clone ID: 1D2-G8-G1]

Specifications

Product Data
Clone Name	1D2-G8-G1
Applications	IF, WB
Recommend Dilution	WB: 1:1000, IF: 1:100
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	The immunogen for NOG antibody: purified recombinant human Noggin protein fragments expressed in E.coli.
Formulation	ascites
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	26 kDa
Gene Name	noggin
Database Link	NP_005441 Entrez Gene 9241 Human UniProt ID Q13253
Background	The secreted polypeptide, encoded by this gene, binds and inactivates members of the transforming growth factor-beta (TGF-beta) superfamily signaling proteins,such as bone morphogenetic protein-4 (BMP4).By diffusing through extracellular matrices more efficiently than members of the TGF-beta superfamily,this protein may have a principal role in creating morphogenic gradients.The protein appears to have pleiotropic effect,both early in development as well as in later stages.It was originally isolated from Xenopus based on its ability to restore normal dorsal-ventral body axis in embryos that had been artificially ventralized by UV treatment.The results of the mouse knockout of the ortholog suggest that it is involved in numerous developmental processes,such as neural tube fusion and joint formation. Recently,several dominant human NOG mutations in unrelated families with proximal symphalangism (SYM1) and multiple synostoses syndrome (SYNS1) were identified;both SYM1 and SYNS1 have multiple joint fusion as their principal feature,and map to the same region (17q22) as this gene.All of these mutations altered evolutionarily conserved amino acid residues.The amino acid sequence of this human gene is highly homologous to that of Xenopus,rat and mouse. [provided by RefSeq,Jul 2008]
Synonyms	SYM1; SYNS1; SYNS1A
Reference Data
Protein Families	Druggable Genome, Secreted Protein
Protein Pathways	TGF-beta signaling pathway

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