LCK Mouse Monoclonal Antibody [Clone ID: 3E5-C8-B9]

Specifications

Product Data
Clone Name	3E5-C8-B9
Applications	WB
Recommend Dilution	WB: 1:1000
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	The immunogen for LCK antibody: purified recombinant human LCK protein fragments expressed in E.coli.
Formulation	Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.02% sodium azide, 50%,glycerol
Purification	Affinity purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	58 kDa
Gene Name	LCK proto-oncogene, Src family tyrosine kinase
Database Link	NP_001036236 Entrez Gene 3932 Human UniProt ID P06239
Background	This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein is a key signaling molecule in the selection and maturation of developing T-cells. It contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to the plasma membrane and pericentrosomal vesicles, and binds to cell surface receptors, including CD4 and CD8, and other signaling molecules. Multiple alternatively spliced variants, encoding the same protein, have been described.
Synonyms	IMD22; LSK; p56lck; pp58lck; YT16
Reference Data
Protein Families	Druggable Genome, Protein Kinase, Stem cell - Pluripotency
Protein Pathways	Natural killer cell mediated cytotoxicity, Primary immunodeficiency, T cell receptor signaling pathway

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