KIAA1967 (CCAR2) Mouse Monoclonal Antibody [Clone ID: 3G4-D11-D7]

Specifications

Product Data
Clone Name	3G4-D11-D7
Applications	IF, IP, WB
Recommend Dilution	WB: 1:500, IF: 1:200
Reactivity	Human, Mouse, Rat, Monkey
Host	Mouse
Clonality	Monoclonal
Immunogen	The immunogen for KIAA1967 antibody: purified recombinant human DBC1 protein fragments expressed in E.coli
Formulation	Purified mouse monoclonal antibody in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.02% sodium azide, 50%,glycerol
Purification	Affinity purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	130 kDa
Gene Name	cell cycle and apoptosis regulator 2
Database Link	NP_066997 Entrez Gene 219158 MouseEntrez Gene 306007 RatEntrez Gene 57805 Human UniProt ID Q8N163
Background	Core component of the DBIRD complex,a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing:the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions.Inhibits SIRT1 deacetylase activity leading to increasing levels of p53/TP53 acetylation and p53-mediated apoptosis.Inhibits SUV39H1 methyltransferase activity.As part of a histone H3-specific methyltransferase complex may mediate ligand-dependent transcriptional activation by nuclear hormone receptors.
Synonyms	DBC-1; DBC1; KIAA1967; NET35; p30 DBC; p30DBC
Reference Data

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