GRP78 (HSPA5) Mouse Monoclonal Antibody [Clone ID: 9E4-2A7-H6]

Specifications

Product Data
Clone Name	9E4-2A7-H6
Applications	IF, IHC, WB
Recommend Dilution	WB: 1:1000, IF: 1:50
Reactivity	Human, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	The immunogen for HSPA5 antibody: purified recombinant human BiP/GRP78 (C-terminus) protein fragments expressed in E.coli.
Formulation	Purified mouse monoclonal antibody in PBS(pH 7.4) containing with 0.02% sodium azide and 50% glycerol.
Purification	Affinity purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	78 kDa
Gene Name	heat shock protein family A (Hsp70) member 5
Database Link	NP_005338 Entrez Gene 25617 RatEntrez Gene 3309 Human UniProt ID P11021
Background	The 78 kDa glucose regulated protein/BiP (GRP78) belongs to the family of ~70 kDa heat shock proteins (HSP 70). GRP78 is a resident protein of the endoplasmic reticulum (ER) and may associate transiently with a variety of newly synthesized secretory and membrane proteins or permanently with mutant or defective proteins that are incorrectly folded, thus preventing their export from the ER lumen. GRP78 is a highly conserved protein that is essential for cell viability. The highly conserved sequence Lys-Asp-Glu-Leu (KDEL) is present at the C terminus of GRP78 and other resident ER proteins including glucose regulated protein 94 (GRP 94) and protein disulfide isomerase (PDI). The presence of carboxy terminal KDEL appears to be necessary for retention and appears to be sufficient to reduce the secretion of proteins from the ER. This retention is reported to be mediated by a KDEL receptor.
Synonyms	BIP; GRP78; HEL-S-89n; MIF2
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Antigen processing and presentation, Prion diseases

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