HDAC3 Mouse Monoclonal Antibody [Clone ID: 3G3-H6-H10]

Specifications

Product Data
Clone Name	3G3-H6-H10
Applications	WB
Recommend Dilution	WB: 1:1000
Reactivity	Human, Mouse, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	The immunogen for HDAC3 antibody: purified recombinant human HDAC3 protein fragments expressed in E.coli.
Formulation	ascites
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	49 kDa
Gene Name	histone deacetylase 3
Database Link	NP_003874 Entrez Gene 15183 MouseEntrez Gene 84578 RatEntrez Gene 8841 Human UniProt ID O15379
Background	Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene.
Synonyms	HD3; RPD3; RPD3-2
Reference Data
Protein Families	Druggable Genome, Transcription Factors

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