FEN1 Mouse Monoclonal Antibody [Clone ID: 7H8-F4-C11]

CAT#: TA346946

Mouse Monoclonal FEN-1 Antibody

Size: 20 ul 100 ul



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CNY 2,700.00


货期*
2周

规格
    • 100 ul

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Specifications

Product Data
Clone Name 7H8-F4-C11
Applications IF, WB
Recommend Dilution WB: 1:1000
Reactivity Human, Mouse, Rat, Hamster, Monkey
Host Mouse
Clonality Monoclonal
Immunogen The immunogen for FEN1 antibody: purified recombinant human FEN-1 protein fragments expressed in E.coli.
Formulation Purified mouse monoclonal antibody in PBS(pH 7.4) containing with 0.02% sodium azide and 50% glycerol.
Purification Affinity purified
Conjugation Unconjugated
Storage Condition Store at -20°C as received.
Predicted Protein Size 45 kDa
Gene Name flap structure-specific endonuclease 1
Background The protein encoded by this gene removes 5' overhanging flaps in DNA repair and processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis. Direct physical interaction between this protein and AP endonuclease 1 during long-patch base excision repair provides coordinated loading of the proteins onto the substrate,thus passing the substrate from one enzyme to another.The protein is a member of the XPG/RAD2 endonuclease family and is one of ten proteins essential for cell-free DNA replication.DNA secondary structure can inhibit flap processing at certain trinucleotide repeats in a length-dependent manner by concealing the 5' end of the flap that is necessary for both binding and cleavage by the protein encoded by this gene.Therefore,secondary structure can deter the protective function of this protein,leading to site-specific trinucleotide expansions. [provided by RefSeq,Jul 2008]
Synonyms FEN-1; MF1; RAD2
Reference Data
Protein Families Druggable Genome, Stem cell - Pluripotency
Protein Pathways Base excision repair, DNA replication, Non-homologous end-joining
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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