Pyruvate Dehydrogenase E2 (DLAT) Mouse Monoclonal Antibody [Clone ID: 4A4-B6-C10]

Specifications

Product Data
Clone Name	4A4-B6-C10
Applications	IF, IP, WB
Recommend Dilution	WB: 1:1000, IF: 1:300
Reactivity	Human, Mouse
Host	Mouse
Clonality	Monoclonal
Immunogen	The immunogen for DLAT antibody: purified recombinant human Pyruvate Dehydrogenase E2 protein fragments expressed in E.coli.
Formulation	Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.02% sodium azide, 50%,glycerol
Purification	Affinity purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	69 kDa
Gene Name	dihydrolipoamide S-acetyltransferase
Database Link	NP_001922 Entrez Gene 235339 MouseEntrez Gene 1737 Human UniProt ID P10515
Background	This gene encodes component E2 of the multi-enzyme pyruvate dehydrogenase complex (PDC). PDC resides in the inner mitochondrial membrane and catalyzes the conversion of pyruvate to acetyl coenzyme A. The protein product of this gene, dihydrolipoamide acetyltransferase, accepts acetyl groups formed by the oxidative decarboxylation of pyruvate and transfers them to coenzyme A. Dihydrolipoamide acetyltransferase is the antigen for antimitochondrial antibodies. These autoantibodies are present in nearly 95% of patients with the autoimmune liver disease primary biliary cirrhosis (PBC). In PBC, activated T lymphocytes attack and destroy epithelial cells in the bile duct where this protein is abnormally distributed and overexpressed. PBC enventually leads to cirrhosis and liver failure. Mutations in this gene are also a cause of pyruvate dehydrogenase E2 deficiency which causes primary lactic acidosis in infancy and early childhood
Synonyms	DLTA; PDC-E2; PDCE2
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Citrate cycle (TCA cycle), Glycolysis / Gluconeogenesis, Metabolic pathways, Pyruvate metabolism

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