DCTN1 Mouse Monoclonal Antibody [Clone ID: 3D5-C6-D5]

Specifications

Product Data
Clone Name	3D5-C6-D5
Applications	IP, WB
Recommend Dilution	WB: 1:500
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	The immunogen for DCTN1 antibody: purified recombinant Dynactin 1 protein fragments expressed in E.coli
Formulation	Purified mouse monoclonal antibody in PBS(pH 7.4) containing with 0.02% sodium azide and 50% glycerol.
Purification	Affinity purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	150 kDa
Gene Name	dynactin subunit 1
Database Link	NP_004073 Entrez Gene 1639 Human UniProt ID Q14203
Background	This gene encodes the largest subunit of dynactin,a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150kD.Dynactin binds to both microtubules and cytoplasmic dynein.Dynactin is involved in a diverse array of cellular functions,including ER-to-Golgi transport,the centripetal movement of lysosomes and endosomes,spindle formation,chromosome movement,nuclear positioning, and axonogenesis.This subunit interacts with dynein intermediate chain by its domains directly binding to dynein and binds to microtubules via a highly conserved glycine-rich cytoskeleton-associated protein (CAP-Gly) domain in its N-terminus.Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms.Mutations in this gene cause distal hereditary motor neuronopathy type VIIB (HMN7B) which is also known as distal spinal and bulbar muscular atrophy (dSBMA). [provided by RefSeq, Oct 2008]
Synonyms	DAP-150; DP-150; P135
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Huntington's disease

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