TORC1 (CRTC1) Mouse Monoclonal Antibody [Clone ID: 3D7-E5-D9]

Specifications

Product Data
Clone Name	3D7-E5-D9
Applications	FC, IF, IP, WB
Recommend Dilution	WB: 1:1000, IF: 1:300, FC: 1:100
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	The immunogen for CRTC1 antibody: purified recombinant human MECT1 / Torc1 protein fragments expressed in E.coli.
Formulation	Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.02% sodium azide, 50%,glycerol
Purification	Affinity purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	78 kDa
Gene Name	CREB regulated transcription coactivator 1
Database Link	NP_056136 Entrez Gene 23373 Human UniProt ID Q6UUV9
Background	Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). In the hippocampus, involved in late-phase long-term potentiation (L-LTP) maintenance at the Schaffer collateral-CA1 synapses (By similarity)
Synonyms	MECT1; TORC-1; TORC1; WAMTP1
Reference Data
Protein Families	Transcription Factors

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