HP1 gamma (CBX3) Mouse Monoclonal Antibody [Clone ID: 5G10-F7-A12]

Specifications

Product Data
Clone Name	5G10-F7-A12
Applications	IF, IHC, IP, WB
Recommend Dilution	WB: 1:1000, IF: 1:200
Reactivity	Human, Monkey, Mouse, Hamster, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	The immunogen for CBX3 antibody: purified recombinant human HP1-gamma protein fragments expressed in E.coli.
Formulation	Purified mouse monoclonal antibody in PBS(pH 7.4) containing with 0.02% sodium azide and 50% glycerol.
Purification	Affinity purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	22 kDa
Gene Name	chromobox 3
Database Link	NP_009207 Entrez Gene 12417 MouseEntrez Gene 297093 RatEntrez Gene 11335 Human UniProt ID Q13185
Background	At the nuclear envelope, the nuclear lamina and heterochromatin are adjacent to the inner nuclear membrane. The protein encoded by this gene binds DNA and is a component of heterochromatin. This protein also can bind lamin B receptor, an integral membrane protein found in the inner nuclear membrane. The dual binding functions of the encoded protein may explain the association of heterochromatin with the inner nuclear membrane. This protein binds histone H3 tails methylated at Lys-9 sites. This protein is also recruited to sites of ultraviolet-induced DNA damage and double-strand breaks. Two transcript variants encoding the same protein but differing in the 5' UTR, have been found for this gene. [provided by RefSeq, Mar 2011]
Synonyms	HECH; HP1-GAMMA; HP1Hs-gamma
Reference Data
Protein Families	Druggable Genome, Transcription Factors

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