BTK Mouse Monoclonal Antibody [Clone ID: 5B12-C9-F10]

Specifications

Product Data
Clone Name	5B12-C9-F10
Applications	WB
Recommend Dilution	WB: 1:1000
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	The immunogen for BTK antibody: purified recombinant human BTK protein fragments expressed in E.coli.
Formulation	Purified mouse monoclonal antibody in PBS(pH 7.4) containing with 0.02% sodium azide and 50% glycerol.
Purification	Affinity purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	77 kDa
Gene Name	Bruton tyrosine kinase
Database Link	NP_000052 Entrez Gene 695 Human UniProt ID Q06187
Background	The protein encoded by this gene plays a crucial role in B-cell development. Mutations in this gene cause X-linked agammaglobulinemia type 1, which is an immunodeficiency characterized by the failure to produce mature B lymphocytes, and associated with a failure of Ig heavy chain rearrangement. Alternative splicing results in multiple transcript variants encoding different isoforms.
Synonyms	AGMX1; AT; ATK; BPK; IMD1; PSCTK1; XLA
Reference Data
Protein Families	Druggable Genome, Protein Kinase
Protein Pathways	B cell receptor signaling pathway, Fc epsilon RI signaling pathway, Primary immunodeficiency

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