Bone Sialoprotein (IBSP) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	The immunogen for anti-IBSP antibody: synthetic peptide directed towards the N terminal of human IBSP. Synthetic peptide located within the following region: SATTLGYGEDATPGTGYTGLAAIQLPKKAGDITNKATKEKESDEEEEEEE
Formulation	Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. Note that this product is shipped as lyophilized powder to China customers.
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	35 kDa
Gene Name	integrin binding sialoprotein
Database Link	NP_004958 Entrez Gene 3381 Human UniProt ID P21815
Background	The protein encoded byThis gene is a major structural protein ofThe bone matrix. It constitutes approximately 12% ofThe noncollagenous proteins in human bone and is synthesized by skeletal-associated cell types, including hypertrophic chondrocytes, osteoblasts, osteocytes, and osteoclasts.The only extraskeletal site of its synthesis isThe trophoblast.This protein binds to calcium and hydroxyapatite via its acidic amino acid clusters, and mediates cell attachment through an RGD sequence that recognizesThe vitronectin receptor. [provided by RefSeq, Jul 2008]
Synonyms	BNSP; BSP; BSP-II; SP-II
Note	Immunogen Sequence Homology: Human: 100%; Dog: 79%
Reference Data
Protein Families	Druggable Genome, Secreted Protein
Protein Pathways	ECM-receptor interaction, Focal adhesion

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