IL17E (IL25) Mouse Monoclonal Antibody [Clone ID: 8B1]

Specifications

Product Data
Clone Name	8B1
Applications	FC, WB
Recommend Dilution	Western Blot: 0.5-2ug/ml, Flow Cytometry: 1-2ug/ml
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Full-length human IL17E recombinant protein was used as the immunogen for this antibody.
Formulation	PBS containing 0.05% BSA, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Concentration	lot specific
Purification	Protein G purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	interleukin 25
Database Link	NP_758525 Entrez Gene 64806 Human UniProt ID Q9H293
Background	As a member of the IL-17 family, IL-25 has been identified as a pro-inflammatory cytokine which is produced by Th17 effector cells thus enabling the TH17 subset to initiate or maintain the autoimmune process in diseases such as Rheumatoid Arthritis (1-3). IL-25 appears to stimulate IL-8 production and itself appears to be activated through IL-23, IL-6, and TGF-Beta (1). Studies of IL-25 expression and activation through NF-kB taken together with IL-17 production and Th17 polarization through TLR ligand activation further closely tie the IL-17 and Th17 family together with the TLR signaling network initiating and controlling immune responses (4-7).
Synonyms	IL17E
Reference Data
Protein Families	Druggable Genome, Secreted Protein, Transmembrane
Protein Pathways	Cytokine-cytokine receptor interaction

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