BST2 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	FC, IHC, Simple Western, WB
Recommend Dilution	Immunohistochemistry, Western Blot: 2 - 4 ug/mL, Immunohistochemistry-Paraffin: 5 ug/mL, Immunofluorescence, Simple Western: 1:200, Flow Cytometry, Flow (Cell Surface), Immunohistochemistry-Frozen
Reactivity	Human, Mouse, Rat, Primate
Host	Rabbit
Clonality	Polyclonal
Immunogen	A portion of amino acids 80-130 of human BST2 was used as the immunogen for this antibody.
Formulation	PBS containing 0.05% BSA, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Concentration	lot specific
Purification	Protein A purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	bone marrow stromal cell antigen 2
Database Link	NP_004326 Entrez Gene 69550 MouseEntrez Gene 378947 RatEntrez Gene 684 Human UniProt ID Q10589
Background	BST2, also known as CD317, HM1.24 antigen, DAMP-2 and recently designated tetherin, is an integral membrane protein with a novel topology. The specific function of the BST2, encoded by the bone marrow stromal cell antigen 2 gene, is undetermined; however, it may play a role in pre-B-cell growth, rheumatoid arthritis, and in antiretroviral defense, that blocks release of retrovirus from the cell surface. BST2 is highly expressed during B-cell development, from pro-B precursors to plasma cells, T-cells, monocytes, Nk cells and DCs (at protein level).
Synonyms	CD317; TETHERIN
Note	BST2 is a 180 amino acid protein with an observed molecular weight of approximately 30 kDa in western blotting (see Ishikawa et all, 1995 PMID 7607676). FLOW application of this product is reported by Crother et al 2011 PMID 21695198.
Reference Data
Protein Families	Druggable Genome, ES Cell Differentiation/IPS, Transmembrane

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