Synaptophysin (SYP) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ICC/IF, IHC, WB
Recommend Dilution	Immunohistochemistry-Frozen, Immunohistochemistry: 1:100, Immunocytochemistry/ Immunofluorescence: 1:250, Western Blot: 1.0 ug/ml, Immunohistochemistry-Paraffin: 1:100
Reactivity	Human, Mouse, Primate
Host	Rabbit
Clonality	Polyclonal
Immunogen	A synthetic peptide made to an C-terminal portion of the human Synaptophysin protein (between residues 230-313) [UniProt P08247]
Formulation	PBS, 0.02% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Concentration	lot specific
Purification	Immunogen affinity purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	synaptophysin
Database Link	NP_003170 Entrez Gene 20977 MouseEntrez Gene 6855 Human UniProt ID P08247
Background	Communication in the nervous system is dependent on the exocytosis of neurotransmitter-containing synaptic vesicles that release their contents at the synapses following membrane depolarization. Synaptophysin (SYP) is a major 38 kDa tetraspan membrane protein of small synaptic vesicles that plays an essential role in targeting synaptic vesicles to the presynaptic membrane. Synaptophysin directly interacts with the essential membrane fusion v-SNARE protein, synaptobrevin/VAMP2, and targets it to the presynaptic membrane (PMID: 14528015). Thus, synaptophysin is required for proper targeting of VAMP2 and synaptic vesicles. Synaptophysin is localized to the trans-Golgi cisternae and then accumulates to the presynaptic membrane in a microtubule dependent manner (PMID: 8227215).
Synonyms	MRX96; MRXSYP
Reference Data
Protein Families	Secreted Protein, Transmembrane

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