LOX Rabbit Polyclonal Antibody

CAT#: TA337077

Rabbit Polyclonal LOX Antibody



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CNY 5,381.00


货期*
5周

规格
    • 100 ul

Cited in 1 publication.

Product images

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Recombinant protein of human lysyl oxidase (LOX), 20 µg
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Specifications

Product Data
Applications ICC/IF, IHC, IP, WB
Recommend Dilution Immunohistochemistry, Knockout Validated, Immunocytochemistry/ Immunofluorescence: 1:10-1:500, Immunoprecipitation: 1:10-1:500, Western Blot: 1:100-1:2000, Immunohistochemistry-Paraffin: 1:10-1:500, Immunohistochemistry-Frozen
Reactivity Human, Mouse, Rat, Bovine, Primate
Host Rabbit
Clonality Polyclonal
Immunogen Within the range of amino acids 305-338 of human LOX protein were used as the immunogen.
Formulation Crude whole Rabbit sera with 50% Glycerol, 0.025% Sodium Azide
Concentration lot specific
Purification Whole antisera
Conjugation Unconjugated
Storage Condition Store at -20°C as received.
Gene Name lysyl oxidase
Background LOX (lysyl oxidase) is a copper-dependent amine oxidase enzyme responsible for post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. LOX is synthesized as an inactive 50 kD proenzyme that is N-glycosylated in ER/Golgi complex and then secreted into extracellular environment, where it is processed by pro-collagen C-proteinases (mammalian Tolloids and BMP-1) into an active enzyme (28-32 kD) and an 18 kD propeptide (LOX-PP) which can be N-glycosylated intracellularly into a ~35 kD form. LOX activity is critical in maintaining the tensile as well as elastic features of the connective tissues of skeletal, pulmonary and cardiovascular systems. LOX deficiency leads to intra-gestational lethality in LOX-/- mice wherein the pups exhibits aortic aneurysms/tortuosity/rupture. LOX expression is highly regulated during normal development; and, its aberrant expression or activity has been documented in a range of diseases predominantly associated with the ECM such as Cutis laxa or OHS (occipital horn syndrome), Menkes' syndrome, myocardial ischaemia/heart failure, atherosclerosis, scleroderma, liver cirrhosis, Pseudoexfoliation syndrome and glaucoma, Alzheimer's/non-Alzheimer's dementia, Wilson's disease, primary biliary cirrhosis as well as in many type of cancers, wherein LOX implicates in promoting tumor cell invasion and metastasis.
Synonyms MGC105112
Reference Data
Protein Families Druggable Genome, Secreted Protein
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

Citations (1)

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