Tryptophan 5 hydroxylase 2 (TPH2) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	Western Blot: 2 ug/ml
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	A synthetic peptide made to an N-terminal portion of the human Tryptophan hydroxylase 2 protein (between residues 100-200) [UniProt Q8IWU9]
Formulation	PBS, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Concentration	lot specific
Purification	Immunogen affinity purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	tryptophan hydroxylase 2
Database Link	NP_775489 Entrez Gene 121278 Human UniProt ID Q8IWU9
Background	TPH2 is a protein of the pterin dependent aromatic acid hydroxylase family. It catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. TPH2 is expressed predominantly in the central nervous system. Mutations in TPH2 gene may be associated with psychiatric diseases such as bipolar affective disorder and major depression.
Synonyms	ADHD7; NTPH
Note	This Tryptophan hydroxylase 2 antibody is useful in Western blot, where a band is seen ~50 kDa.
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Metabolic pathways, Tryptophan metabolism

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