Synaptophysin (SYP) Mouse Monoclonal Antibody [Clone ID: 7H12]

Specifications

Product Data
Clone Name	7H12
Applications	ELISA, IHC, WB
Recommend Dilution	ELISA: 1:10000, Immunohistochemistry, Western Blot: 1:500 - 1:2000, Immunohistochemistry-Paraffin: 1:200 - 1:1000
Reactivity	Human, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Purified recombinant fragment of human Synaptophysin expressed in E. coli. [UniProt# P08247]
Formulation	Preservative: 0.05% Sodium Azide. Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Concentration	lot specific
Purification	Ascites
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	33.8 kDa
Gene Name	synaptophysin
Database Link	NP_003170 Entrez Gene 24804 RatEntrez Gene 6855 Human UniProt ID P08247
Background	Synaptophysin (p38) is an integral membrane protein of small synaptic vesicles in brain and endocrine cells.Synaptophysin contains four transmembrane domains that form a hexameric channel or gap junction-like pore. Synaptophysin binds to the SNARE protein synaptobrevin/VAMP, which prevents the inclusion of synaptobrevin in the synaptic vesicle fusion complex and creates a pool of synaptobrevin for exocytosis when synapse activity increases. Synaptophysin is also responsible for targeting synaptobrevin 2/VAMP2 to synaptic vesicles, a critical component of the fusion complex.
Synonyms	MRX96; MRXSYP
Note	This Synaptophysin (7H12) antibody is useful in Western Blot, ELISA, and Immunohistochemistry on paraffin-embedded sections.
Reference Data
Protein Families	Secreted Protein, Transmembrane

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