beta III Tubulin (TUBB3) Mouse Monoclonal Antibody [Clone ID: 2E9]

Specifications

Product Data
Clone Name	2E9
Applications	ELISA, FC, ICC/IF, IHC, Simple Western, WB
Recommend Dilution	Simple Western: 1:500, Flow Cytometry: 1:200-1:400, ELISA: 1:10000, Immunocytochemistry/ Immunofluorescence: 1:200-1:1000, Western Blot: 1:500-1:2000, Immunohistochemistry
Reactivity	Human, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Purified recombinant fragment of human Tubulin Beta 3 expressed in E. coli. [UniProt# Q13509]
Formulation	Preservative: 0.05% Sodium Azide. Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Concentration	lot specific
Purification	Ascites
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	50 kDa
Gene Name	tubulin beta 3 class III
Database Link	NP_006077 Entrez Gene 246118 RatEntrez Gene 10381 Human UniProt ID Q13509
Background	Tubulin Beta 3 is abundant in the central and peripheral nervous systems (CNS and PNS) where it is prominently expressed during fetal and postnatal development. As exemplified in cerebellar and sympathoadrenal neurogenesis, the distribution of Tubulin Beta 3 is neuron-associated, exhibiting distinct temporospatial gradients according to the regional neuroepithelia of origin. However, transient expression of this protein is also present in the subventricular zones of the CNS comprising putative neuronal- and/or glial precursor cells, as well as in Kulchitsky neuroendocrine cells of the fetal respiratory epithelium. This temporally restricted, potentially non-neuronal expression may have implications in the identification of presumptive neurons derived from embryonic stem cells. In adult tissues, the distribution of Tubulin Beta 3 is almost exclusively neuron-specific.
Synonyms	beta-4; CDCBM; CDCBM1; CFEOM3; CFEOM3A; FEOM3; TUBB4
Note	This Tubulin Beta 3 (2E9) antibody is useful in Western Blot, Immunocytochemistry/Immunofluorescence, Flow cytometry and ELISA.
Reference Data
Protein Families	Druggable Genome, ES Cell Differentiation/IPS
Protein Pathways	Gap junction, Pathogenic Escherichia coli infection

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