CD57 (B3GAT1) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ICC/IF, IHC
Recommend Dilution	Immunohistochemistry: 1:100, Immunocytochemistry/ Immunofluorescence: 1:100, Immunohistochemistry-Paraffin: 1:400
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	A synthetic peptide made to an N-terminal portion of the human CD57 protein (between residues 1-50) [UniProt Q9P2W7]
Formulation	PBS with 30% Glycerol, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Concentration	lot specific
Purification	Affinity purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	beta-1,3-glucuronyltransferase 1
Database Link	NP_473366 Entrez Gene 76898 MouseEntrez Gene 117108 RatEntrez Gene 27087 Human UniProt ID Q9P2W7
Background	CD57 (also known as beta-1,3-glucuronyltransferase 1, Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1, Glucuronosyltransferase P, Human Natural Killer 1, B3GAT1, NK1, HNK1, LEU7, NK-1, GLCUATP, and GLCATP) is a member of the glucuronyltransferase gene family. The enzymes produced by the members of this family recognize non-reducing terminal sugars and their anomeric linkages by exhibiting strong acceptor specificity. CD57 is also involved in the biosynthesis of glycosaminoglycan and L2/HNK-1 carbohydrate epitopes on glycoproteins. CD57 is expressed mainly in the brain and several alternate transcriptional splice variants have been characterized. In cancer research, CD57 positive lymphocytes have been used successfully in monitoring the progression of various cancers (PMID: 21491089). HNK1 is also involved in synaptic plasticity and neurodevelopment (PMID: 20950796).
Synonyms	CD57; GLCATP; GLCUATP; HNK1; LEU7; NK-1; NK1
Note	Prior to immunostaining paraffin tissues, antigen retrieval with sodium citrate buffer (pH 6.0) is recommended.
Reference Data
Protein Families	Transmembrane
Protein Pathways	Chondroitin sulfate biosynthesis, Heparan sulfate biosynthesis, Metabolic pathways

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