SCARB1 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	Block/Neutralize, ICC/IF, IHC, IP, WB
Recommend Dilution	Immunocytochemistry/ Immunofluorescence: 1:50-1:200, Immunoprecipitation: 1:100, Western Blot: 1:500, Block/Neutralize, Immunohistochemistry-Frozen, Immunohistochemistry-Paraffin: 1:100, Immunohistochemistry: 1:100
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Adenovirus encoding mouse SR-BI. [UniProt# Q61009]
Formulation	Tris-citrate/phosphate, pH 7, 0.1% Sodium azide. Store at 4C. Do not freeze.
Concentration	lot specific
Purification	Whole antisera
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	scavenger receptor class B member 1
Database Link	NP_005496 Entrez Gene 20778 MouseEntrez Gene 25073 RatEntrez Gene 949 Human UniProt ID Q8WTV0
Background	SR-BI (scavenger receptor class B member 1, SCARB1) belongs to CD36 family and act as a receptor for several ligands including phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and HDL located in caveolae (regions over plasma membrane). It plays important role in meditating the uptake of HDL-derived cholesterol as well as cholesteryl ester in liver and steroidogenic tissues. It facilitates the flux of free and esterified cholesterol between cell surface and extracellular donors and acceptors, such as HDL and to a lesser extent, apoB-containing lipoproteins and modified lipoproteins. SR-BI is expressed in endothelial cells, macrophages and dendritic cells also. It has been suggested to be involved in the phagocytosis of apoptotic cells (via its phosphatidylserine binding activity); uptake of lipid soluble vitamins (vitamin E and carotenoids) and pathogen recognition, anti-inflammatory responses and its expression can be modulated by LPS as well as ROS. SR-BI has also been involved in the capture and cross-presentation of antigens from viruses, bacteria and parasites.
Synonyms	CD36L1; CLA-1; CLA1; HDLQTL6; SR-BI; SRB1
Note	This SR-BI antibody is useful for Flow Cytometry (PMID 22622498), Immunocytochemistry/Immunofluorescence, Immunoprecipitation, Western blot and for blocking the binding of ligands to SR-BI. Immunohistochemistry-Frozen was reported in scientific literature.
Reference Data
Protein Families	Druggable Genome, Transmembrane

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