IGF2R Mouse Monoclonal Antibody [Clone ID: 2G11]

Specifications

Product Data
Clone Name	2G11
Applications	CyTOF-ready, ELISA, FC, ICC/IF, IHC, IP, WB
Recommend Dilution	Flow Cytometry: 1 ug per million cells, ELISA, Immunohistochemistry: 1:100, Immunocytochemistry/ Immunofluorescence: 1:10-1:250, Immunoprecipitation: 1:10-1:500, Western Blot: 1 ug/ml, Immunohistochemistry-Paraffin: 1:100, CyTOF-ready
Reactivity	Human, Rat, Bovine, Primate
Host	Mouse
Clonality	Monoclonal
Immunogen	Purified bovine Mannose 6 Phosphate Receptor (Cation independent) [UniProt# P08169]
Formulation	PBS containing 0.05% BSA, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Concentration	lot specific
Purification	Protein A purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	insulin like growth factor 2 receptor
Database Link	NP_000867 Entrez Gene 25151 RatEntrez Gene 3482 Human UniProt ID P11717
Background	Mannose 6 phosphate is a sequence tag that plays a pivotal role in delivering proteins to the lysosome. Specifically, the mannose 6 phosphate sequence is tagged to N-linked oligosaccharides of lysosomal hydrolases as they pass through the cis-Golgi network. Once the lysosomal enzymes are tagged with the M6P sequence, they are destined to the late endosome by way of vesicular transport. After a low pH dissociates the M6P Receptor from its ligand, the M6P sequences are recycled. Additionally, M6P is bound by lectin in the immune system, and is converted to fructose 6-phosphate by mannose phosphate isomerase.
Synonyms	CD222; CIMPR; M6P-R; MPR1; MPRI
Note	By Western Blot, a 300 kDa protein representing Mannose 6 Phosphate Receptor is seen in HeLa cell extract under non-reducing conditions. Immunofluorescence staining of Mannose 6 Phosphate Receptor in HeLa cells with this antibody results in perinuclear staining. This antibody is also useful in Flow Cytometry, Immunoprecipitation, ELISA and Immunohistochemistry-on parraffin embedded sections.
Reference Data
Protein Families	Druggable Genome, Transmembrane
Protein Pathways	Lysosome

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