SIAH2 Mouse Monoclonal Antibody [Clone ID: 24E6H3]

Specifications

Product Data
Clone Name	24E6H3
Applications	FC, ICC/IF, IHC, WB
Recommend Dilution	Immunohistochemistry-Frozen: 1:40-1:50, Flow Cytometry: 1:10, Flow (Intracellular), Immunohistochemistry: 1:40-1:50, Immunocytochemistry/ Immunofluorescence: 1:10, Western Blot, Immunohistochemistry-Paraffin: 1:40-1:50
Reactivity	Human, Drosophila, Porcine
Host	Mouse
Clonality	Monoclonal
Immunogen	Synthetic peptide made to an N-terminal portion of the drosophila SINA protein (within residues 1-100). [Swiss-Prot# P21461]
Formulation	Preservative: 0.1% Sodium Azide. Store at 4C. Do not freeze.
Concentration	lot specific
Purification	Tissue culture supernatant
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	siah E3 ubiquitin protein ligase 2
Database Link	NP_005058 Entrez Gene 20439 MouseEntrez Gene 6478 Human UniProt ID O43255
Background	The Drosophila SINA (seven in absentia) protein is an E3 ubiquitin ligase component of the RAS signal transduction pathway. The RAS signal pathway controls cell proliferation, differentiation, and survival, and regulation of this pathway is critical for normal development. In Drosophila SINA serves as a downstream gatekeeper required for proper RAS signal transduction. Similarly to SINA in Drosophila, the human protein SIAH has also been shown to be required for oncogenic RAS signaling in cancer.
Synonyms	hSiah2
Note	This SIAH2 (24E6H3) antibody is useful for Flow Cytometry, Immunocytochemistry/Immunofluorescence and Immunohistochemistry on paraffin-embedded and frozen sections.
Reference Data
Protein Families	Druggable Genome, Transcription Factors

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