TTC11 (FIS1) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB: 1:500 - 1:1000, IHC-P: 1:100
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Amino acids 11-25 of human Fis1 protein were used as the immunogen.
Formulation	Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Concentration	lot specific
Purification	Whole antisera
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	fission, mitochondrial 1
Database Link	NP_057152 Entrez Gene 66437 MouseEntrez Gene 288584 RatEntrez Gene 51024 Human UniProt ID Q9Y3D6
Background	Principal Names: CGI-135, Fis1, Fis1 homolog, H_NH0132A01.6, tetratricopeptide repeat domain 11, TPR repeat protein 11 ; Claudin 15; CLDN15; TTC11 Official Gene Symbol: TTC11 Gene ID: 51024 (Human) Gene Map Locus: 7q22.1 (Human) Fis1, a 17KDa integral membrane protein, is a novel member of mitochondrial fission machinery. It consists of a central leucine-zipper domain, a coiled-coil region, a tetratricopeptide repeat domain and a C-terminal transmembrane domain. It is a human orthologue of Fis1p (S.cerevisiae) and is localized in the outer mitochondrial membrane. Fis1 acts as a pro-apoptotic factor and plays a vital role in the regulation of mitochondrial fission. It interacts with DLP1 and Mdv1p and facilitates Dnm1p recruitment to the functional fission complex, thereby inducing apoptosis. Role of Fis1 has also been implicated in growth and division of peroxisomes. Loss of Fis1 inhibits apoptosis and results in elongation of mammalian mitochondria.
Synonyms	CGI-135; TTC11
Note	Immunohistochemistry (paraffin): See Wang et al, 2009 for details.
Reference Data
Protein Families	Transmembrane

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