TEM8 (ANTXR1) Mouse Monoclonal Antibody [Clone ID: 200C1339(SB20)]

Specifications

Product Data
Clone Name	200C1339(SB20)
Applications	IHC, WB
Recommend Dilution	Western Blot: 1-3 ug/ml, Immunohistochemistry: 2-5 ug/ml, Immunohistochemistry-Paraffin: 2-5 ug/ml, Immunocytochemistry/ Immunofluorescence)
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	This monoclonal antibody was developed by immunizing mice with a synthetic peptide containing amino acids 481-497 (CINFTRVKNNQPAKYPL) of human TEM8.
Formulation	PBS containing 0.05% BSA, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Concentration	lot specific
Purification	Protein G purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	anthrax toxin receptor 1
Database Link	NP_444262 Entrez Gene 84168 Human UniProt ID Q9H6X2
Background	Recently, using SAGE (Serial Analysis of Gene Expression) technology, St. Croix et al, have identified 46 genes, whose expression is specifically elevated in tumor-associated endothelium. Nine of these genes were prominently expressed only in tumor endothelial cells (EC), but were absent or barely detectable in normal ECs, and named as Tumor Endothelial Markers (TEMs, TEM 1-9). Based on TEM8s interaction with the C5 domain of collagen a3(VI), a protein also preferentially expressed in tumor endothelium, it is thought that TEM8 plays an important role in tumor angiogenesis.
Synonyms	ATR; GAPO; TEM8
Note	Immunohistochemistry-Paraffin: see Hotchkiss et al 2005 for details. Immunocytochemistry/Immunofluorescence: See Matsuda (2010) for details.
Reference Data
Protein Families	Druggable Genome, Transmembrane

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