APIP Mouse Monoclonal Antibody [Clone ID: 19F461]

Specifications

Product Data
Clone Name	19F461
Applications	IHC, WB
Recommend Dilution	Immunohistochemistry-Paraffin, Immunohistochemistry: 5 ug/ml, Western Blot: 1-2 ug/ml
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	The antibody was developed against a full-length His-tagged recombinant APIP.
Formulation	PBS containing 0.05% BSA, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Concentration	lot specific
Purification	Protein G purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	APAF1 interacting protein
Database Link	NP_057041 Entrez Gene 51074 Human UniProt ID Q96GX9
Background	The mammalian homologues of the key cell death gene CED-4 in C. elegans has been identified recently from human and mouse and designated Apaf1 (for apoptosis protease-activating factor 1). Apaf1 binds to cytochrome c (Apaf2) and caspase-9 (Apaf3), which leads to caspase-9 activation. Activated caspase-9 in turn cleaves and activates caspase-3 that is one of the key proteases, being responsible for the proteolytic cleavage of many key proteins in apoptosis3. Recently, Cho et al have identified a new Apaf-1 Interactiong Protein (APIP) also known as CG129 and MMRP19, as a negative regulator of ischemic injury. APIP competes with Caspase-9 binding site of Apaf1. APIP is predicted to code for a 204 amino acid. An isoform of APIP, APIP2 encodes a 242 amino acid protein, which is an alternative splicing variant differing in its N-terminus from APIP. APIP transcript is ubiquitously expressed in most adult tissue with high expression in skeletal muscle, heart, and kidney.
Synonyms	APIP2; CGI-29; CGI29; hAPIP; MMRP19
Reference Data
Protein Pathways	Cysteine and methionine metabolism, Metabolic pathways

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