Corticotropin Releasing Factor Receptor 2 (CRHR2) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ICC/IF, Simple Western, WB
Recommend Dilution	Immunocytochemistry/ Immunofluorescence, Simple Western: 1:200, Western Blot: 0.5-2 ug/ml
Reactivity	Human, Mouse, Rat, Bovine, Canine, Chicken
Host	Rabbit
Clonality	Polyclonal
Immunogen	A portion of amino acids 75-125 of human CRHR2 was used as the immunogen.
Formulation	PBS containing 0.05% BSA, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Concentration	lot specific
Purification	Protein G purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	corticotropin releasing hormone receptor 2
Database Link	NP_001874 Entrez Gene 12922 MouseEntrez Gene 64680 RatEntrez Gene 1395 Human UniProt ID Q13324
Background	CRHR2 is a novel member of Secretin-family-GPCR proteins that functions as a functional receptor for CRF. It is expressed as 3 isoforms; alpha, beta and gamma. These isoforms primarily differ in their N-terminal sequence and tissue distribution. Apart from CRF, other ligands of CRHR2 include UcnI, UcnII and UcnIII. CRHR2 is involved in stress responses, cardiovascular function and gastric motility. Studies on CRHR2 deficient mice suggested a central anxiolytic effect of CRHR2. Northern Blot analysis detects CRHR2 expression in brain, hypothalamus, heart, GI, lung, skeletal muscle and vasculature.
Synonyms	CRF-RB; CRF2; CRFR2; HM-CRF
Reference Data
Protein Families	Druggable Genome, Transmembrane
Protein Pathways	Neuroactive ligand-receptor interaction

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