SMAD2 Rabbit Polyclonal Antibody

CAT#: TA336363

Rabbit Polyclonal Smad2 Antibody



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CNY 5,381.00


货期*
5周

规格
    • 100 ug

Product images

经常一起买 (4)
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Recombinant protein of human SMAD family member 2 (SMAD2), transcript variant 1, 20 µg
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Recombinant protein of human SMAD family member 2 (SMAD2), transcript variant 2, 100 µg
    • 100 ug

CNY 9,998.00

Specifications

Product Data
Applications IHC, WB
Recommend Dilution Immunohistochemistry, Immunohistochemistry-Paraffin: 5 ug/ml, Western Blot: 2-4 ug/ml
Reactivity Human, Mouse, Rat, Bovine, Canine, Chicken, Primate
Host Rabbit
Clonality Polyclonal
Immunogen Amino acids 234-249 (DQQLNQSMDTGSPAEL) of human SMAD2 protein was used as the immunogen.
Formulation PBS containing 0.05% BSA, 0.05% Sodium Azide. Store at 4C. Do not freeze.
Concentration lot specific
Purification Protein G purified
Conjugation Unconjugated
Storage Condition Store at -20°C as received.
Gene Name SMAD family member 2
Background SMAD2 is an intracellular protein belonging to the Dwarfin (DWA/B)/SMAD family. SMAD2 associates with SMAD4 for translocation to nucleus. It acts as an intracellular mediator of TGFbeta family of cytokines and activin type 1 receptor (ACVR1C). Hence it regulates multiple cellular processes like cell growth, proliferation, differentiation, and apoptosis and also cooperates with transcription factors to regulate expression of defined genes. Apart from playing an important role in TGFbeta1-induced CTGF expression they also act as markers of EMT in human PTECs. It also acts as an integrator of multiple signals in the regulation of NOS3 expression. It is ubiquitously expressed in most of the tissues and is responsible for colorectal, hepatocellular, lung and breast carcinomas as well as cervical cancer.
Synonyms hMAD-2; hSMAD2; JV18; JV18-1; MADH2; MADR2
Reference Data
Protein Families Cancer stem cells, Druggable Genome, Embryonic stem cells, ES Cell Differentiation/IPS, Stem cell relevant signaling - JAK/STAT signaling pathway, Stem cell relevant signaling - TGFb/BMP signaling pathway, Transcription Factors
Protein Pathways Adherens junction, Cell cycle, Colorectal cancer, Pancreatic cancer, Pathways in cancer, TGF-beta signaling pathway, Wnt signaling pathway
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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