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PPM1D Rabbit Polyclonal Antibody
CAT＃: TA332984S
Rabbit anti-PPM1D Polyclonal Antibody
Size: 100 ul
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CNY 800.00
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Specifications
| Product Data | |
| Applications | WB |
| Recommend Dilution | WB 1:500 - 1:2000 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Immunogen | Recombinant protein of human PPM1D |
| Formulation | Store at -20°C (regular) and -80°C (long term). Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Concentration | lot specific |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage Condition | Store at -20°C as received. |
| Predicted Protein Size | 605 |
| Gene Name | protein phosphatase, Mg2+/Mn2+ dependent 1D |
| Database Link | |
| Background | The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. The expression of this gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase, MAPK/p38, through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis. This gene is located in a chromosomal region known to be amplified in breast cancer. The amplification of this gene has been detected in both breast cancer cell line and primary breast tumors, which suggests a role of this gene in cancer development. |
| Synonyms | PP2C-DELTA; WIP1 |
| Reference Data | |
| Protein Families | Druggable Genome, Phosphatase |
| Protein Pathways | p53 signaling pathway |
Documents
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