Tapasin (TAPBP) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ICC/IF, IHC, WB
Recommend Dilution	WB 1:500 - 1:2000;IF 1:10 - 1:100
Reactivity	Mouse, Human, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Recombinant protein of human TAPBP
Formulation	Store at -20°C (regular) and -80°C (long term). Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Concentration	lot specific
Purification	Affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	47 kDa
Gene Name	TAP binding protein (tapasin)
Database Link	NP_757345 Entrez Gene 21356 MouseEntrez Gene 6892 Human UniProt ID O15533
Background	This gene encodes a transmembrane glycoprotein which mediates interaction between newly assembled major histocompatibility complex (MHC) class I molecules and the transporter associated with antigen processing (TAP), which is required for the transport of antigenic peptides across the endoplasmic reticulum membrane. This interaction is essential for optimal peptide loading on the MHC class I molecule. Up to four complexes of MHC class I and this protein may be bound to a single TAP molecule. This protein contains a C-terminal double-lysine motif (KKKAE) known to maintain membrane proteins in the endoplasmic reticulum. This gene lies within the major histocompatibility complex on chromosome 6. Alternative splicing results in three transcript variants encoding different isoforms.
Synonyms	NGS17; TAPA; TPN; TPSN
Reference Data
Protein Families	Druggable Genome, Transmembrane
Protein Pathways	Antigen processing and presentation

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