14-3-3 beta (YWHAB) Rabbit Polyclonal Antibody

CAT#: TA332392S

Rabbit anti-YWHAB Polyclonal Antibody

Size: 20 ul 100 ul



Need it in bulk or conjugated?
Get a free quote

CN¥ 800.00


货期*
3周

规格
    • 20 ul

Product images

Specifications

Product Data
Applications ICC/IF, IHC, IP, WB
Recommend Dilution WB 1:500 - 1:2000;IF 1:50- 1:200
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Immunogen Recombinant protein of human YWHAB
Formulation PBS with 0.09% Sodium azide,50% glycerol,pH7.3.
Concentration lot specific
Purification Affinity purification
Conjugation Unconjugated
Storage Condition Store at -20°C as received.
Predicted Protein Size 246
Gene Name tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta
Background 3-3 proteins are highly conserved and ubiquitously expressed. There are at least seven isoforms, β, γ, ε, Ï?, ζ, Ï?, and η that have been identified in mammals. The initially described α and δ isoforms are confirmed to be phosphorylated forms of β and ζ, respectively (3). Through their amino-terminal α helical region, 14-3-3 proteins form homo- or heterodimers that interact with a wide variety of proteins: transcription factors, metabolic enzymes, cytoskeletal proteins, kinases, phosphatases, and other signaling molecules (3,4). The interaction of 14-3-3 proteins with their targets is primarily through a phospho-Ser/Thr motif. However, binding to divergent phospho-Ser/Thr motifs, as well as phosphorylation-independent interactions, has been observed (4). 14-3-3 binding masks specific sequences of the target protein and therefore modulates target protein localization, phosphorylation state, stability, and molecular interactions (1-4). 14-3-3 proteins may also induce target protein conformational changes that modify target protein function (4,5). Distinct temporal and spatial expression patterns of 14-3-3 isoforms have been observed in development and in acute response to extracellular signals and drugs, suggesting that 14-3-3 isoforms may perform different functions despite their sequence similarities (4). Several studies suggest that 14-3-3 isoforms are differentially regulated in cancer and neurological syndromes (2,3).
Synonyms GW128; HEL-S-1; HS1; KCIP-1; YWHAA
Reference Data
Protein Families Druggable Genome
Protein Pathways Cell cycle, Neurotrophin signaling pathway, Oocyte meiosis
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
Customer Reviews 
Loading...