MADH7 (SMAD7) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	The immunogen for anti-SMAD7 antibody: synthetic peptide directed towards the N terminal of human SMAD7. Synthetic peptide located within the following region: EEEGAGGGGGGGELRGEGATDSRAHGAGGGGPGRAGCCLGKAVRGAKGHH
Formulation	Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. Note that this product is shipped as lyophilized powder to China customers.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	46 kDa
Gene Name	SMAD family member 7
Database Link	NP_005895 Entrez Gene 4092 Human UniProt ID O15105
Background	Smad7 acts to functionally inactivate RB and de-repress E2F without blocking the activation of TbetaRI and the nuclear translocation of Smad2/3, allowing TGF-beta1 to exert effects in a cancer cell that is resistant to TGF-beta1-mediated growth inhibition.
Synonyms	CRCS3; MADH7; MADH8
Note	Immunogen sequence homology: Human: 100%; Dog: 93%; Pig: 93%; Bovine: 93%; Rabbit: 93%; Mouse: 92%; Rat: 85%
Reference Data
Protein Families	Druggable Genome, Transcription Factors
Protein Pathways	TGF-beta signaling pathway

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