alpha 1 Fetoprotein (AFP) Goat Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 0.3-1ug/ml, ELISA: 1:128,000
Reactivity	Human
Host	Goat
Clonality	Polyclonal
Immunogen	Internal region (KDALTAIEKPTGDEQ)
Formulation	Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.
Concentration	lot specific
Purification	Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	alpha fetoprotein
Database Link	NP_001125 Entrez Gene 174 Human UniProt ID P02771
Background	Alpha-fetoprotein (AFP) is a serum glycoprotein protein produced in the liver or yolk sac of fetal staged mammals. AFP synthesis is minimal after birth and trace amount is expressed in the adult liver (1). AFP gene expression is regulated by the interactions between steroid hormone receptors and transcriptional factors in separate signal transduction pathways (2). AFP functions as a binding and transporting ligand and cell growth regulator. Elevated expression level of AFP has been implicated in colorectal, ovarian, pancreatic, testicular, and certain liver cancers. High levels of AFP is also seen in some diseases such as hepatitis and colitis. AFP is used as a screening marker for fetal abnormalities in pregnant women such as Down syndrome. Recently, AFP has been introduced as an anti-cancer drugs-ligand carrier, transporting drugs to target tumor cells, increasing anti-tumor efficiency (3).
Synonyms	AFPD; FETA; HPAFP
Reference Data
Protein Families	Druggable Genome, Secreted Protein

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