Tmem38a Rabbit Polyclonal Antibody
CNY 11,000.00
货期*
7周
规格
经常一起买 (1)
beta Actin Mouse Monoclonal Antibody, Clone OTI1, Loading Control
CNY 300.00
CNY 1,430.00
Specifications
Product Data | |
Applications | IF, IHC, WB |
Recommend Dilution | WB: 1:200-1:2000; IHC: 1:100-1:3000 |
Reactivity | Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | Peptide (C)DNHGAPHGMGLGTQHS, corresponding to amino acid residues 259-274 of rat (Accession A6ZIQ8). Intracellular, C-terminus. |
Formulation | Lyophilized. Concentration before lyophilization ~0.8mg/ml (lot dependent, please refer to CoA along with shipment for actual concentration). Buffer before lyophilization: Phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3. |
Reconstitution Method | Add 50 ul double distilled water (DDW) to the lyophilized powder. |
Purification | Affinity purified on immobilized antigen. |
Conjugation | Unconjugated |
Storage Condition | Store at -20°C as received. |
Gene Name | transmembrane protein 38a |
Database Link | |
Background | Intracellular Ca2+ levels are important in proper cellular functions and have prominent roles in various cell signaling pathways and are crucial for muscle contractions. Indeed, an important step leading to muscle contraction is the massive release of Ca2+ ions from the endoplasmic /sarcoplasmic reticulum (ER/SR) to the cytosol. A battery of results suggest that specific K+ channels are important to counteract the Ca2+ outflow in order to neutralize the negative potential created by the movement of Ca2+ ions. It is believed that TRIC channels are responsible for neutralizing this negative potential. Trimeric intracellular cation-specific (TRIC) channels are critical for proper management of intracellular stores. TRIC-A and TRIC-B both belong to this family and are both permeable to monovalent ions with a preference for K+ . Both channels are localized to the ER/SR membrane. Each TRIC subunit contains three transmembrane domains, a cytoplasmic C-terminus and a luminal N-terminus. Functional entities are formed by homotrimerizarion. The activity of TRIC-A is regulated by voltage whereas that of TRIC-B can be regulated by different mechanisms. Knock out studies of these channels have shown that TRIC-A knock mice are viable while those of TRIC-B die at the neonatal stage. TRIC-A is mostly expressed in excitable tissues like the brain and muscle while TRIC-B is ubiquitously expressed. |
Synonyms | MGC3169; TRIC-A; TRICA |
Reference Data |
Documents
Product Manuals |
FAQs |
SDS |
Resources
抗体相关资料 |
其它Tmem38a产品
Customer
Reviews
Loading...