Kcnmb4 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 1:200-1:2000; IHC: 1:100-1:3000
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Peptide AKLRVSYEYTEAEDKS(C), corresponding to amino acid residues 2-17 of rat sloÃ?4. Intracellular, N-terminal part.
Formulation	Lyophilized. Concentration before lyophilization ~0.8mg/ml (lot dependent, please refer to CoA along with shipment for actual concentration). Buffer before lyophilization: Phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.025% NaN3.
Reconstitution Method	Add 50 ul double distilled water (DDW) to the lyophilized powder.
Purification	Affinity purified on immobilized antigen.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	potassium calcium-activated channel subfamily M regulatory beta subunit 4
Database Link	NP_076450 Entrez Gene 27345 HumanEntrez Gene 58802 MouseEntrez Gene 66016 Rat UniProt ID Q9ESK8
Background	sloÃ?4 is a member of a family of regulatory b subunits that control the activity of the large conductance Ca2+-activated K+ channel KCa1.1. The family includes four members with a shared topology: two trans-membrane domains, short intracellular N- and C-termini and a large extracellular region.The four members of the family have a distinct tissue distribution with sloÃ?4 expressed almost exclusively in the central nervous sytem (CNS).Functionally, sloÃ?4 increases the sensitivity of the pore-forming KCa1.1 subunit to Ca2+ and voltage and it also changes its pharmacology. It has been shown that co-expression of sloÃ?4 with KCa1.1 makes the latter resistant to nM concentrations of the well-known inhibitors Charybdotoxin and Iberiotoxin.The physiological significance of sloÃ?4 expression in the CNS is not clear, but KCa1.1 channels are likely involved in the regulation of neurotransmitter release in presynaptic terminals.
Synonyms	BKbeta4; Hbeta4; K(VCA)beta-4; Slo-beta-4
Reference Data

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