Kcnj15 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 1:200-1:2000
Reactivity	Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Peptide (C)EKQKLEEQYRQEDQRERELR, corresponding to amino acid residues 347-366 of mouse Kir4.2. Intracellular, C-terminal part.
Formulation	Lyophilized. Concentration before lyophilization ~0.8mg/ml (lot dependent, please refer to CoA along with shipment for actual concentration). Buffer before lyophilization: Phosphate buffered saline (PBS), pH 7.4, 1% BSA, 5% sucrose, 0.025% NaN3.
Reconstitution Method	Add 50 ul double distilled water (DDW) to the lyophilized powder.
Purification	Affinity purified on immobilized antigen.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	potassium inwardly-rectifying channel, subfamily J, member 15
Database Link	NP_062638 Entrez Gene 16516 Mouse UniProt ID O88932
Background	Kir4.2 is a member of the family of inward rectifying K+ channels. The family includes 15 members that are structurally and functionally different from the voltage-dependent K+ channels. The familyâ??s topology consists of two transmembrane domains that flank a single and highly conserved pore region with intracellular N- and C-termini. As is the case for the voltage-dependent K+ channels the functional unit for the Kir channels is composed of four subunit that can assembly as either homo or heteromers. Kir channels are characterized by a K+ efflux that is limited by depolarizing membrane potentials thus making them essential for controlling resting membrane potential and K+ homeostasis. Kir4.2 is a member of the Kir4 subfamily that includes one other member: Kir4.1. Kir4.2 can co-assemble with Kir4.1 but also with other Kir channels such as Kir1.1 and Kir5.1.2 The Kir4 subfamily has been classified as weak rectifiers with intermediate conductance. Kir4.2 is expressed in liver, kidney, pancreas lung and testis. Its physiological function is not well understood but it has been suggested that it could be involved in the regulation of K+ efflux in epithelial cells such as hepatocytes or lung cells.
Synonyms	IRKK; KCNJ14; Kir1.3; Kir4.2; MGC13584; OTTHUMP00000115739; OTTHUMP00000115740
Reference Data

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