Kcnmb1 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 1:200-1:2000; IHC: 1:100-1:3000
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Peptide KKLVMAQKRGETRALC, corresponding to amino acid residues 2-17 of rat sloÃ?1. Intracellular, N-terminal part.
Formulation	Lyophilized. Concentration before lyophilization ~0.8mg/ml (lot dependent, please refer to CoA along with shipment for actual concentration). Buffer before lyophilization: phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3.
Reconstitution Method	Add 50 ul double distilled water (DDW) to the lyophilized powder.
Purification	Affinity purified on immobilized antigen.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	potassium calcium-activated channel subfamily M regulatory beta subunit 1
Database Link	NP_062146 Entrez Gene 3779 HumanEntrez Gene 16533 MouseEntrez Gene 29747 Rat UniProt ID P97678
Background	sloÃ?1 is a member of a family of regulatory Ã? subunits that control the activity of the large conductance Ca2+-activated K+ channel KCa1.1. The family includes four members with a shared topology: two trans-membrane domains, short intracellular N- and C-termini and a large extracellular region. The four members of the family have a distinct tissue distribution with sloÃ?1 expressed almost exclusively in smooth muscle. Functionally, sloÃ?1 increases the sensitivity of the pore-forming KCa1.1 subunit to Ca2+ and voltage and it also changes its pharmacology. In the past few years there has been a lot interest regarding the role of the sloÃ?1 subunit in the regulation of vascular tone and hypertension. Studies in sloÃ?1 knockout mice have shown that loss of this subunit results in systemic hypertension. Conversely, a recent study showed that a commonly found gain-of-function sloÃ?1 variant has a protective effect against human diastolic hypertension.
Synonyms	BKbeta; BKbeta1; Hbeta1; hslo-beta; K(VCA)beta; K(VCA)beta-1; Slo-beta; Slo-beta-1
Reference Data

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