Kcnc4 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 1:200-1:2000; IHC: 1:100-1:3000
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Peptide EAGDD ERELA LQRLG PHEG(C), corresponding to amino acid residues 177-195 of rat Kv3.4. Intracellular, N-terminal.
Formulation	Lyophilized. Concentration before lyophilization ~0.8mg/ml (lot dependent, please refer to CoA along with shipment for actual concentration). Buffer before lyophilization: Phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.025% NaN3.
Reconstitution Method	Add 50 ul double distilled water (DDW) to the lyophilized powder.
Purification	Affinity purified on immobilized peptide.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	potassium voltage-gated channel subfamily C member 4
Database Link	NP_001116248 Entrez Gene 3749 HumanEntrez Gene 99738 MouseEntrez Gene 684516 Rat UniProt ID Q63734
Background	Kv3.4 is a member of the voltage-gated K+ channel superfamily. Together with the related proteins Kv3.1, Kv3.2 and Kv3.3 they constitute the Shaw type subfamily family. As with all Kv channels, Kv3.4 possesses the signature structure of the voltage-dependent K+ channels: six membrane-spanning domains with intracellular N and C termini. The functional Kv channel is a tetramer that can either be a homomer or a heteromer of Kv3 subunits. Kv3 subfamily members inactivate very rapidly and therefore are thought to play a role in the repolarization of action potentials and to facilitate repetitive high frequency firing. Kv3.4 expression is wide and the channel can be found in brain, skeletal muscle, prostate and pancreas among others.Kv3.4 subunits have been implicated recently in the response mechanism to chronic hypoxia and the etiology of Alzheimer's and Parkinson's diseases. In addition, Kv3.4 was found to associate with the auxiliary subunit KCNE3 (MirP2) in skeletal muscle. A mutation in KCNE3 (R83H) has been associated with an inherited form of periodic paralysis (Thyrotoxic hypokalemic periodic paralysis) that is caused by the altered physiological function of the Kv3.4 channel.
Synonyms	HKSHIIIC; KSHIIIC; KV3.4; MGC126818
Reference Data

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