Cacna2d4 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, IHC, WB
Recommend Dilution	WB: 1:200-1:2000; IHC: 1:100-1:3000
Reactivity	Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Peptide (C)SERPQEMGRLLGEADG, corresponding to amino acid residues 881-896 of mouse Cava2d4. Extracellular.
Formulation	Lyophilized. Concentration before lyophilization ~0.8mg/ml (lot dependent, please refer to CoA along with shipment for actual concentration). Buffer before lyophilization: phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3.
Reconstitution Method	Add 50 ul double distilled water (DDW) to the lyophilized powder.
Purification	Affinity purified on immobilized antigen.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	calcium channel, voltage-dependent, alpha 2/delta subunit 4
Database Link	NP_001028554 Entrez Gene 312668 RatEntrez Gene 319734 Mouse UniProt ID Q5RJF7
Background	Voltage-gated Ca2+ (CaV) channels are ubiquitously expressed and function as Ca2+ conducting pores in the plasma membrane. Based on their electrophysiological and pharmacological properties, Ca2+ channels have traditionally been classified into L, T, N, P, Q, and R types. L-type calcium channels are heteromultimers composed of four independently encoded proteins, the pore-forming a1 subunit, which triggers Ca2+ flow across the membrane, and the auxiliary subunits a2d, ?, and Ã?. The Ca2+ channel a2d subunit is a heavily glycosylated protein that is encoded by a single gene and post-translationally cleaved to yield a2 and d subunits linked by a disulfide bond with a single transmembrane segment.The a2d subunit regulates many functional aspects of Ca2+ channels, such as gating, regulating voltage dependent kinetics, and increasing functional channel density on the plasma membrane. There are four proteins that comprise CaVa2d: CaVa2d1, CaVa2d2, CaVa2d3 and CaVa2d4. CaVa2d4 participates in the regulation of membrane expression of CaV channels. It is predominantly expressed in certain types of endocrine cells. It is also detected in the erythroblasts in the fetal liver, in the cells of the zona reticularis of the adrenal gland and in the basophiles of the pituitary. Defects in CaVa2d4 are the cause of retinal cone dystrophy 4 (RCD4). RCD4 is characterized by minimal symptoms except for slowly progressive reduction in visual acuity.
Synonyms	RCD4
Note	This antibody was tested in live cell imaging. Please see IF/ICC data for detail.
Reference Data

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