Rabbit Monoclonal Antibody

Specifications

Product Data
Reactivity	Human, Rat
Host	Rabbit
Clonality	Monoclonal
Immunogen	Peptide EPFPSAVTIKSWVDK(C), corresponding to amino acid residues 27-41 of rabbit a2d1 precursor).Extracellular, N-terminus.
Formulation	Lyophilized. Concentration before lyophilization ~0.8mg/ml (lot dependent, please refer to CoA along with shipment for actual concentration). Buffer before lyophilization: phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3.
Reconstitution Method	Add 50 ul double distilled water (DDW) to the lyophilized powder.
Purification	Affinity purified on immobilized antigen.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Background	The a2d1 protein is an auxiliary subunit of the CaV (voltage dependent calcium) channel multimer complex. Four a2d isoforms were identified in mammalian genoms and they share some sequence as well as structure homology. The protein product of the gene encoding a2d is complex, it includes two seperated proteins the extracellular a2 linked by disulphide bridges to the membrane sppaning (single transmembrane helix) d subunit. a2d1 subunit is highly expressed in skeletal muscle and brain. Its expression along with a pore forming CaV a1 subunit, result in larger CaV currents, probably due to improoved trafficing of the a1 subunit to the plasma membrane. a2d1 subunit was shown to be the target of the antiepileptic and anelgestic drug gabapentin.
Reference Data

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.