Cacna1c Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 1:200-1:2000; IHC: 1:100-1:3000
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Peptide (C)DNFDYLTRDWSILGPHHLD, corresponding to amino acid residues 1506-1524 of rat Cav1.2. Intracellular, C-terminus region.
Formulation	Lyophilized. Concentration before lyophilization ~0.8mg/ml (lot dependent, please refer to CoA along with shipment for actual concentration). Buffer before lyophilization: phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3.
Reconstitution Method	Add 50 ul double distilled water (DDW) to the lyophilized powder.
Purification	Affinity purified on immobilized antigen.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	calcium voltage-gated channel subunit alpha1 C
Database Link	NP_036649 Entrez Gene 775 HumanEntrez Gene 12288 MouseEntrez Gene 24239 Rat UniProt ID P22002
Background	Ca2+ ions regulate many cellular processes such as secretion, proliferation, and apoptosis and they are also cofactors of many proteins. In neurons, Ca2+ entry through voltage-dependent Ca2+ (Cav) channels triggers neurotransmitter release. Fast synaptic transmission in the mammalian central nervous system (CNS) is mediated by several high voltage-dependent Ca2+ channels.Five types of Ca2+ channels are expressed in the CNS: the L-type (Cav1), N-type (Cav2.2), P/Q-type (Cav2.1), R-type (Cav2.3), and the T-type (Cav3).4 Each Cav channel is a multimeric protein composed of a pore forming a1 subunit and the auxiliary Ã? (CavÃ?), a2d and ? subunits. There are four known CavÃ? subunits, in addition to four a2d subunits and eight ? subunits.
Synonyms	CACH2; CACN2; CACNL1A1; CaV1.2; CCHL1A1; MGC120730; OTTHUMP00000196730; OTTHUMP00000196731; OTTHUMP00000196732; OTTHUMP00000196733; OTTHUMP00000196734; OTTHUMP00000196735; OTTHUMP00000196736; OTTHUMP00000196737; OTTHUMP00000196739; OTTHUMP00000196744; OTTHUMP00000196746; OTTHUMP00000196747; OTTHUMP00000196748; OTTHUMP00000196749; OTTHUMP00000196751; TS
Reference Data

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